Methodology for assessing the impact of emergencies on the spread of infectious diseases

Dmytro Chumachenko, Kseniia Bazilevych, Mykola Butkevych, Ievgen Meniailov, Yurii Parfeniuk, Ievgen Sidenko, Tetyana Chumachenko

Abstract


The spread of infectious diseases is significantly influenced by emergencies, particularly military conflicts, which disrupt healthcare systems and increase the risks of epidemics. The full-scale Russian invasion of Ukraine has exacerbated these challenges, causing environmental damage, mass displacement, and the breakdown of healthcare services, all of which contribute to the spread of infectious diseases. This study aims to develop a comprehensive methodology for assessing the impact of emergencies on the spread of infectious diseases, focusing on the full-scale invasion of Ukraine. The object of this study is to address epidemic threats posed by emergencies, particularly the increased spread of infectious diseases due to war-related disruptions. The subject of this study is methods and models of infectious disease transmission under conditions of emergencies, emphasizing the Russian full-scale invasion of Ukraine. The tasks of this study are to provide an analysis of the current state of research and develop a methodology for assessing the impact of emergencies on the spread of infectious diseases. The proposed methodology includes several key components. Comprehensive data from public health organizations includes infectious disease statistics, demographic shifts, healthcare disruptions, and environmental factors exacerbated by emergencies. Data preprocessing removes inconsistencies, standardization of formats, and normalization for population size differences. Machine learning models, including convolutional neural networks and recurrent neural networks, have been developed to simulate the spread of diseases based on demographic, environmental, and healthcare-related variables. Deep learning models analyze spatial and temporal patterns, whereas compartmental models such as SIR estimate changes in reproductive numbers (R₀ and Re). Additionally, models of excess mortality incorporate mixed effects to account for regional and time-based variations. The methodology incorporates real-time monitoring of epidemic threats using real-time data from multiple sources, enabling dynamic assessments of disease spread and facilitating predictive modeling. The models were trained on historical data and validated using cross-validation techniques to ensure robustness and reliability, with a specific focus on the pre- and post-invasion phases in Ukraine.Results: The study provides a comprehensive framework for collecting and processing data on infectious diseases and epidemic threats in emergencies. The proposed model introduces advanced machine learning and epidemiological models trained on pre- and post-invasion data to analyze disease transmission patterns and forecast future epidemic dynamics. Conclusion: The proposed methodology addresses current gaps in infectious disease during emergencies by integrating real-time data and machine learning techniques. This research improves decision-making in public health management and biosafety during crises, particularly in war-affected regions like Ukraine.

Keywords


epidemic model; emergency; war; epidemic process; simulation; infectious disease

Full Text:

PDF

References


Hao, R., Liu, Y., Shen, W., Zhao, R., Jiang, B., Song, H., Yan, M., Ma, H. Surveillance of Emerging Infectious Diseases for Biosecurity. Science China Life Sciences, 2022, vol. 65, pp. 1504–1516. DOI: 10.1007/s11427-021-2071-x.

Bendavid, E., Boerma, T., Akseer, N., Langer, A., Malembaka, E.B., Okiro, E.A., Wise, P.H., Heft-Neal, S., Black, R.E., Bhutta, Z.A. et al. The Effects of Armed Conflict on the Health of Women and Children. The Lancet, 2021, vol. 397, pp. 522–532. DOI: 10.1016/s0140-6736(21)00131-8.

Hryhorczuk, D., Levy, B.S., Prodanchuk, M., Kravchuk, O., Bubalo, N., Hryhorczuk, A., Erickson, T.B. The Environmental Health Impacts of Russia’s War on Ukraine. Journal of Occupational Medicine & Toxicology, 2024, vol. 19, pp. 1–14. DOI: 10.1186/s12995-023-00398-y.

Friedman, S.R., Smyrnov, P., Vasylyeva, T.I. Will the Russian War in Ukraine Unleash Larger Epidemics of HIV, TB and Associated Conditions and Diseases in Ukraine? Harm Reduction Journal, 2023, vol. 20, art. 119. DOI: 10.1186/s12954-023-00855-1.

Sakalauskas, L., Dulskis, V., Jankunas, R.J. Compartmental Modeling for Pandemic Data Analysis: The Gap between Statistics and Models. Heliyon, 2024, vol. 10, art. e31410. DOI: 10.1016/j.heliyon.2024.e31410.

Yang, K., Qi, H. The Optimisation of Public Health Emergency Governance: A Simulation Study Based on COVID-19 Pandemic Control Policy. Globalization and health, 2023, vol. 19, art. 95. DOI: 10.1186/s12992-023-00996-9.

Zhang, P., Feng, K., Gong, Y., Lee, J., Lomonaco, S., Zhao, L. Usage of Compartmental Models in Predicting COVID-19 Outbreaks. The AAPS Journal, 2022, vol. 24, art. 98. DOI: 10.1208/s12248-022-00743-9.

Silal, S.P., Little, F., Barnes, K.I., White, L.J. Sensitivity to Model Structure: A Comparison of Compartmental Models in Epidemiology. Health Systems, 2016, vol. 5, pp. 178–191. DOI: 10.1057/hs.2015.2.

Kharchenko, V.S.; Yastrebenetsky, M.A. About Concept of Big Safety. Reliability: Theory and Applications, 2021, vol. 16, iss. 1, pp. 13–29. DOI: 10.24412/1932-2321-2021-161-13-29.

Goniewicz, K., Burkle, F.M., Horne, S., Borowska-Stefańska, M., Wiśniewski, S., Khorram-Manesh, A. The Influence of War and Conflict on Infectious Disease: A Rapid Review of Historical Lessons We Have yet to Learn. Sustainability, 2021, vol. 13, art. 10783. DOI: 10.3390/su131910783.

Pennington, H. The Impact of Infectious Disease in War Time: A Look Back at WW1. Future Microbiology, 2019, vol. 14, pp. 165–168. DOI: 10.2217/fmb-2018-0323.

Mehtar, S., AlMhawish, N., Shobak, K., Reingold, A., Guha-Sapir, D., Haar, R.J. Measles in Conflict-Affected Northern Syria: Results from an Ongoing Outbreak Surveillance Program. Conflict and Health, 2021, vol. 15, art. 95. DOI: 10.1186/s13031-021-00430-0.

Simpson, R.B., Babool, S., Tarnas, M.C., Kaminski, P.M., Hartwick, M.A., Naumova, E.N. Dynamic Mapping of Cholera Outbreak during the Yemeni Civil War, 2016–2019. Journal of Public Health Policy, 2022, vol. 43, pp. 185–202. DOI: 10.1057/s41271-022-00345-x.

Ergönül, Ö., Tülek, N., Kayı, I., Irmak, H., Erdem, O., Dara, M. Profiling Infectious Diseases in Turkey after the Influx of 3.5 Million Syrian Refugees. Clinical Microbiology and Infection, 2020, vol. 26, pp. 307–312. DOI: 10.1016/j.cmi.2019.06.022.

Daw, M.A. The Impact of Armed Conflict on the Epidemiological Situation of COVID-19 in Libya, Syria and Yemen. Frontiers in Public Health, 2021, vol. 9, art. 667364. DOI: 10.3389/fpubh.2021.667364.

Muhjazi, G., Gabrielli, A.F., Ruiz-Postigo, J.A., Atta, H., Osman, M., Bashour, H., Al Tawil, A., Husseiny, H., Allahham, R., Allan, R. Cutaneous Leishmaniasis in Syria: A Review of Available Data during the War Years: 2011–2018. PLOS Neglected Tropical Diseases, 2019, vol. 13, art. e0007827. DOI: 10.1371/journal.pntd.0007827.

Ottolini, M.G., Cirks, B.T., Madden, K.B., Rajnik, M. Pediatric Infectious Diseases Encountered during Wartime—Part 1: Experiences and Lessons Learned from Armed Conflict in the Modern Era. Current Infectious Disease Reports, 2021, vol. 23, art. 27. DOI: 10.1007/s11908-021-00770-1.

Ngo, N.V., Pemunta, N.V., Muluh, N.E., Adedze, M., Basil, N., Agwale, S. Armed Conflict, a Neglected Determinant of Childhood Vaccination: Some Children Are Left Behind. Human Vaccines & Immunotherapeutics, 2019, vol. 16, pp. 1454–1463. DOI: 10.1080/21645515.2019.1688043.

Xu, H., Barbot, S., Wang, T. Remote Sensing through the Fog of War: Infrastructure Damage and Environmental Change during the Russian-Ukrainian Conflict Revealed by Open-Access Data. Natural Hazards Research, 2024, vol. 4, pp. 1–7. DOI: 10.1016/j.nhres.2024.01.006.

Rudakov, D., Pikarenia, D., Orlinska, O., Rudakov, L., Hapich, H. A Predictive Assessment of the Uranium Ore Tailings Impact on Surface Water Contamination: Case Study of the City of Kamianske, Ukraine. Journal of Environmental Radioactivity, 2023, vol. 268-269, art. 107246. DOI: 10.1016/j.jenvrad.2023.107246.

Filho, W.L., Fedoruk, M., Henrique, J., Splodytel, A., Smaliychuk, A., Szynkowska-Jóźwik, M.I. The Environment as the First Victim: The Impacts of the War on the Preservation Areas in Ukraine. Journal of Environmental Management, 2024, vol. 364, art. 121399. DOI: 10.1016/j.jenvman.2024.121399.

Hossain, M.A., Ferdous, N., Ferdous, E. Crisis-Driven Disruptions in Global Waste Management: Impacts, Challenges and Policy Responses amid COVID-19, Russia-Ukraine War, Climate Change, and Colossal Food Waste. Environmental Challenges, 2024, vol. 14, art. 100807. DOI: 10.1016/j.envc.2023.100807.

Chumachenko, D., Chumachenko, T. Ukraine War: The Humanitarian Crisis in Kharkiv. BMJ, 2022, art. o796. DOI: 10.1136/bmj.o796.

Petakh, P., Kamyshnyі, А., Tymchyk, V.; Armitage, R. Infectious Diseases during the Russian-Ukrainian War – Morbidity in the Transcarpathian Region as a Marker of Epidemic Danger on the EU Border. Public health in practice, 2023, vol. 6, art. 100397. DOI: 10.1016/j.puhip.2023.100397.

Ramírez, C., Durón, R.M. The Russia-Ukraine War Could Bring Catastrophic Public-Health Challenges beyond COVID-19. International Journal of Infectious Diseases, 2022, vol. 120, pp. 44–45. DOI: 10.1016/j.ijid.2022.04.016.

Symochko, L., Pereira, P., Demyanyuk, O., Coelho Pinheiro, M.N., Barcelo, D. Resistome in a Changing Environment: Hotspots and Vectors of Spreading with a Focus on the Russian-Ukrainian War. Heliyon, 2024, vol. 10, art. e32716. DOI: 10.1016/j.heliyon.2024.e32716.

Keesing, F., Belden, L.K., Daszak, P., Dobson, A., Harvell, C.D., Holt, R.D., Hudson, P., Jolles, A., Jones, K.E., Mitchell, C.E. et al. Impacts of Biodiversity on the Emergence and Transmission of Infectious Diseases. Nature, 2010, vol. 468, pp. 647–652. DOI: 10.1038/nature09575.

Schmeller, D.S., Courchamp, F., Killeen, G. Biodiversity Loss, Emerging Pathogens and Human Health Risks. Biodiversity and Conservation, 2020, vol. 29, pp. 3095–3102. DOI: 10.1007/s10531-020-02021-6.

Haque, U., Naeem, A., Wang, S.; Espinoza, J.; Holovanova, I.; Gutor, T.; Bazyka, D.; Galindo, R.; Sharma, S.; Kaidashev, I.P.; et al. The Human Toll and Humanitarian Crisis of the Russia-Ukraine War: The First 162 Days. BMJ Global Health, 2022, vol. 7, art. e009550. DOI: 10.1136/bmjgh-2022-009550.

Wang, M., Yang, B., Liu, Y., Yang, Y., Ji, H., Yang, C. Emerging Infectious Disease Surveillance Using a Hierarchical Diagnosis Model and the Knox Algorithm. Scientific Reports, 2023, vol. 13, art. 19836. DOI: 10.1038/s41598-023-47010-1.

Oidtman, R.J., Omodei, E., Kraemer, M.U.G., Castañeda-Orjuela, C.A., Cruz-Rivera, E., Misnaza-Castrillón, S., Cifuentes, M.P., Rincon, L.E., Cañon, V., de Alarcon, P. et al. Trade-Offs between Individual and Ensemble Forecasts of an Emerging Infectious Disease. Nature Communications, 2021, vol. 12, art. 5379. DOI: 10.1038/s41467-021-25695-0.

Siewe, N., Greening, B., Fefferman, N.H. Mathematical Model of the Role of Asymptomatic Infection in Outbreaks of Some Emerging Pathogens. Tropical Medicine and Infectious Disease, 2020, vol. 5, art. 184. DOI: 10.3390/tropicalmed5040184.

Hewage, I.M., Church, K.E.M., Schwartz, E.J. Investigating the Impact of Vaccine Hesitancy on an Emerging Infectious Disease: A Mathematical and Numerical Analysis. Journal of Biological Dynamics, 2024, vol. 18, art. 2298988. DOI: 10.1080/17513758.2023.2298988.

Jia, P., Yang, J., Li, X. Optimal Control and Cost-Effective Analysis of an Age-Structured Emerging Infectious Disease Model. Infectious Disease Modelling, 2022, vol. 7, pp. 149–169. DOI: 10.1016/j.idm.2021.12.004.

Voinson, M., Smadi, C., Billiard, S. How Does the Host Community Structure Affect the Epidemiological Dynamics of Emerging Infectious Diseases? Ecological Modelling, 2022, vol. 472, art. 110092. DOI: 10.1016/j.ecolmodel.2022.110092.

Sun, G., Jin, Z., Mai, A. Dynamics of a Two-Patch SIR Model with Disease Surveillance Mediated Infection Force. Communications in Nonlinear Science and Numerical Simulation, 2024, vol. 132, art. 107872. DOI: 10.1016/j.cnsns.2024.107872.

Pan, Q., Song, S., He, M. The Effect of Quarantine Measures for Close Contacts on the Transmission of Emerging Infectious Diseases with Infectivity in Incubation Period. Physica A: Statistical Mechanics and its Applications, 2021, vol. 574, art. 125993. DOI: 10.1016/j.physa.2021.125993.

Adak, S., Kar, T.K., Jana, S. A Fuzzy Inference System for Predicting Outbreaks in Emerging Infectious Diseases. Decision analytics journal, 2024, vol. 10, art. 100436. DOI: 10.1016/j.dajour.2024.100436.

Gupta, S., Bhatia, S.K., Arya, N. Effect of Incubation Delay and Pollution on the Transmission Dynamics of Infectious Disease. Annali dell’Universita di Ferrara, 2023, vol. 69, pp. 23–47. DOI: 10.1007/s11565-022-00399-5.

Verbeeck, J., Faes, C., Neyens, T., Hens, N., Verbeke, G., Deboosere, P., Molenberghs, G. A Linear Mixed Model to Estimate COVID‐19‐Induced Excess Mortality. Biometrics, 2021, vol. 79, pp. 417–425. DOI: 10.1111/biom.13578.

Vanella, P., Basellini, U., Lange, B. Assessing Excess Mortality in Times of Pandemics Based on Principal Component Analysis of Weekly Mortality Data—the Case of COVID-19. Genus, 2021, vol. 77, art. 16. DOI: 10.1186/s41118-021-00123-9.

Sirag, E., Gissler, G. Estimating Excess Mortality in Canada during the COVID-19 Pandemic: Statistical Methods Adapted for Rapid Response in an Evolving Crisis. Statistical Journal of the IAOS, 2021, vol. 37, pp. 1–8. DOI: 10.3233/sji-210871.

Dahal, S., Luo, R., Swahn, M.H., Chowell, G. Geospatial Variability in Excess Death Rates during the COVID-19 Pandemic in Mexico: Examining Socio Demographic, Climate and Population Health Characteristics. International Journal of Infectious Diseases, 2021, vol. 113, pp. 347–354. DOI: 10.1016/j.ijid.2021.10.024.

Barnard, S., Chiavenna, C., Fox, S., Charlett, A., Waller, Z., Andrews, N., Goldblatt, P., Burton, P., De Angelis, D. Methods for Modelling Excess Mortality across England during the COVID-19 Pandemic. Statistical Methods in Medical Research, 2021, vol. 31, pp. 1790–1802. DOI: 10.1177/09622802211046384.

Van Rompaye, B., Eriksson, M., Goetghebeur, E. Evaluating Hospital Performance Based on Excess Cause‐Specific Incidence. Statistics in Medicine, 2015, vol. 34, pp. 1334–1350. DOI: 10.1002/sim.6409.

Delbrouck, C., Alonso-García, J. COVID-19 and Excess Mortality: An Actuarial Study. Risks, 2024, vol. 12, art. 61. DOI: 10.3390/risks12040061.

Edrus, R.A., Siri, Z., Haron, M.A., Safari, M.A.M., Kaabar, M.K.A. A Comparative Analysis of the Forecasted Mortality Rate under Normal Conditions and the COVID-19 Excess Mortality Rate in Malaysia. Journal of Mathematics, 2022, vol. 2022, pp. 1–12. DOI: 10.1155/2022/7715078.

Wilasang, C., Modchang, C., Lincharoen, T., Chadsuthi, S. Estimation of Excess All-Cause Mortality due to COVID-19 in Thailand. Tropical Medicine and Infectious Disease, 2022, vol. 7, art. 116. DOI: 10.3390/tropicalmed7070116.

Maruotti, A., Ciccozzi, M., Jona-Lasinio, G. COVID-19-Induced Excess Mortality in Italy during the Omicron Wave. IJID Regions, 2022, vol. 4, pp. 85–87. DOI: 10.1016/j.ijregi.2022.07.005.

Sisk, A., Fefferman, N.H. A Network Theoretic Method for the Basic Reproductive Number for Infectious Diseases. Methods in Ecology and Evolution, 2022, vol. 13, pp. 2503–2515. DOI: 10.1111/2041-210x.13978.

Park, S.W., Bolker, B.M., Champredon, D., Earn, D.J.D., Li, M., Weitz, J.S., Grenfell, B.T., Dushoff, J. Reconciling Early-Outbreak Estimates of the Basic Reproductive Number and Its Uncertainty: Framework and Applications to the Novel Coronavirus (SARS-CoV-2) Outbreak. Journal of The Royal Society Interface, 2020, vol. 17, art. 20200144. DOI: 10.1098/rsif.2020.0144.

Otoo, D., Donkoh, E.K., Kessie, J.A. Estimating the Basic Reproductive Number of COVID-19 Cases in Ghana. European Journal of Pure and Applied Mathematics, 2021, vol. 14, pp. 135–148. DOI: 10.29020/nybg.ejpam.v14i1.3850.

White, L.F., Moser, C.B., Thompson, R.N., Pagano, M. Statistical Estimation of the Reproductive Number from Case Notification Data. American journal of epidemiology, 2020, vol. 190, pp. 611–620. DOI: 10.1093/aje/kwaa211.

Al-Raeei, M. The Basic Reproduction Number of the New Coronavirus Pandemic with Mortality for India, the Syrian Arab Republic, the United States, Yemen, China, France, Nigeria and Russia with Different Rate of Cases. Clinical Epidemiology and Global Health, 2020, vol. 9, pp. 147–149. DOI: 10.1016/j.cegh.2020.08.005.

Brockhaus, E.K., Wolffram, D., Stadler, T., Osthege, M., Mitra, T., Littek, J.M., Krymova, E., Klesen, A.J., Huisman, J.S., Heyder, S. et al. Why Are Different Estimates of the Effective Reproductive Number so Different? A Case Study on COVID-19 in Germany. PLoS Computational Biology, 2023, vol. 19, art. e1011653. DOI: 10.1371/journal.pcbi.1011653.

Lo Presti, A., Vacca, P., Neri, A., Fazio, C., Ambrosio, L., Rezza, G., Stefanelli, P. Estimates of the Reproductive Numbers and Demographic Reconstruction of Outbreak Associated with C:P1.5-1,10-8:F3-6:ST-11(Cc11) Neisseria Meningitidis Strains. Infection, Genetics and Evolution: Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases, 2020, vol. 84, art. 104360. DOI: 10.1016/j.meegid.2020.104360.

Ahmad Alajlan, S., Alhusseini, N.K., Mohammed Basheeruddin Asdaq, S., Mohzari, Y., Alamer, A., Alrashed, A.A., Alamri, A.S., Alsanie, W.F., Alhomrani, M. The Impact of Lockdown Strategies on the Basic Reproductive Number of Coronavirus (COVID-19) Cases in Saudi Arabia. Saudi Journal of Biological Sciences, 2021, vol. 28, pp. 4926–4930. DOI: 10.1016/j.sjbs.2021.06.047.

Kwok, K.O., Wei, W.I., Tang, A., Shan Wong, S.Y., Tang, J.W. Estimation of Local Transmissibility in the Early Phase of Monkeypox Epidemic in 2022. Clinical Microbiology and Infection, 2022, vol. 28, pp. 1653.e1–1653.e3. DOI: 10.1016/j.cmi.2022.06.025.

Huisman, J.S., Scire, J., Angst, D.C., Li, J., Neher, R.A., Maathuis, M.H., Bonhoeffer, S., Stadler, T. Estimation and Worldwide Monitoring of the Effective Reproductive Number of SARS-CoV-2. eLife, 2022, vol. 11, art. e71345. DOI: 10.7554/eLife.71345.




DOI: https://doi.org/10.32620/reks.2024.3.01

Refbacks

  • There are currently no refbacks.